Objective uterine leiomyomas are the most common gynecological benign tumor and greatly affect reproductive health and well-being they are the predominant indication for hysterectomy in premenopausal women. The results indicated that human uterine leiomyomal cells express bcl-2 protein and progesterone enhances its expression, however, sb reduces the expression of bcl-2 protein in human uterine leiomyoma cells. Uterine leiomyomas (uls) are benign tumors occurring in the majority of reproductive aged women despite the high prevalence of these tumors, little is known about their etiology a hallmark of uls is the excessive deposition of extracellular matrix (ecm), primarily collagens. In primary cultured human uterine leiomyoma cells methods ： the effect of pca on cell proliferation and cell cycle progress ion was examined in the primary cultured human uterine leiomyoma cells.
Uterine leiomyoma stem cells promotes tumor growth masanori onoa,b, ping yina, antonia navarroa, of lmsp cells this effect could be blocked by a wnt antagonist cells from human lm exhibit key features of the tumor-initiating cells (13, 14. Overexpression of the anthocyanidin synthase gene in strawberry enhances antioxidant capacity and cytotoxic effects on human hepatic cancer cells an anthocyanin rich strawberry extract induces apoptosis and ros while decreases glycolysis and fibrosis in human uterine leiomyoma cells oncotarget. The proliferation rate of uterine leiomyoma cells was determined the apoptosis rate of uterine leiomyoma cells was determined the phosphorylation levels of egfr from uterine leiomyoma cells were measured objective: to explore the effect of euonine on the proliferation and apoptosis of uterine. Read vitamin d exhibits antiestrogenic effects in human uterine leiomyoma cells, fertility and sterility on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Objective: to determine the effect of tranilast (an antiallergic drug known to suppress fibrosis or to stabilize mast cells) on extracellular matrix production in human leiomyoma and myometrial cells. The effect of leonurus sibiricus on the proliferation inhibition of human uterine leiomyoma cell and expression of gene related cell apoptosis korean medical database , 19, 1–12 (2006) google scholar. Uterine fibroids have distinct gross and microscopic morphologic findings that distinguish them from malignancies several subtypes of leiomyomas exist, as shown in table 1the varying gross and morphologic presentation of uterine fibroids (table 1) demonstrate the limited understanding about the effects of this variable benign tumor on human fertility. Hereditary leiomyomatosis and renal cell cancer (hlrcc) is a rare autosomal dominantly inherited disorder which confers susceptibility to develop cutaneous and uterine leiomyomas and renal cell carcinoma.
Uterine fibroids (also known as leiomyomas or myomas) are the commonest benign uterine tumors, with an estimated incidence of 20%–40% in women during their reproductive years 1,2 they are monoclonal tumors of the uterine smooth muscle cells and consist of large amounts of extracellular matrix that contain collagen, fibronectin, and. Effect of euonine on the proliferation and apoptosis of human uterine leiomyoma cells running title: role of euonine on uterine leiomyoma highlights: the proliferation rate of uterine leiomyoma cells was determined the apoptosis rate of uterine leiomyoma cells was determined. Although in vitro and in vivo reports on the morphologic and proliferative effects of genistein in human uterine leiomyoma and myometrial cells are lacking, a few studies have assessed the effects of structurally similar compounds on these cell types. Human leiomyoma tissues were collected from 20 patients who underwent uterine leiomyomas operations, and leiomyoma cells were primary cultured the leiomyoma cells were treated by gzflc drug serum in different concentrations (10%, 20%, and 30%) and variable treatment time (12 h, 24 h, 36 h, 48 h, and 72 h.
A nude mice leiomyoma model was used to test the effect of four-agents-decoction on leiomyoma grow materials and methods: human leiomyoma cells and myometrial cells were cultured and grown from a pathology proved myoma or normal myometrium respectively. Background the composition of the matrix molecules is important in in vitro cell culture experiments of eg human cancer invasion and vessel formationcurrently, the mouse engelbreth-holm-swarm (ehs) sarcoma -derived products, such as matrigel®, are the most commonly used tumor microenvironment (tme) mimicking matrices for experimental studies. Above effects were seen in normal myom etrial cells cocultured with fb the soluble factors released by tumor-derived of human uterine leiomyoma cells and the production of ecm proteins we also evaluated if this enhanced uterine leiomyoma cell proliferation could be due to the induc. Objective: to evaluate the effects of selective p receptor (pr) modulator cdb4124 on cell proliferation and apoptosis in cultured human uterine leiomyoma smooth muscle (lsm) cells and control myometrial smooth muscle (msm) cells in matched uteri.
Simvastatin potently stimulated leiomyoma cell apoptosis in a manner mechanistically dependent upon apoptotic calcium release from voltage-gated calcium channels therefore, simvastatin possesses antitumor effects that are dependent upon the apoptotic calcium release machinery. Previous studies [11, 12] have proposed that undifferentiated cells are involved in myometrial pathologies, and also leiomyoma onset may be the result of impaired function, proliferation, and differentiation of undifferentiated cells inside the myometrium that are under the effect of ovarian hormones [13, 14. Uterine leiomyoma is the most common benign smooth muscle cell tumor of the myometrium although bcl-2 protein is known to be an apoptosis-inhibiting gene product and to prevent apoptotic cell death in a variety of cells, there are no published data regarding whether human leiomyomas express bcl-2 protein.
33 the effect of gzflc drug serum on cell apoptosis of human uterine leiomyoma cells as shown in figures 2 and 3, the negative control group compared with the blank control group at the concentration of 10% and 20% (12 h) had no significant difference in cells apoptosis rate (), but at 30% it had increased apoptosis rate (), indicating that 30% rats blank serum promoted uterine leiomyoma. Uterine leiomyomas (fibroids or myomas) are benign clonal tumours that arise from the smooth-muscle cells of the human uterus they are clinically apparent in about 25% of women,1 and with newer imaging techniques, the true clinical prevalence may be higher.
To test this hypothesis, human uterine leiomyoma (utlm) and normal uterine smooth muscle cell (utsmc) lines were treated with bbr, and their proliferation, apoptosis, and expression of related genes was determined. We previously demonstrated that berberine (bbr) inhibits cell proliferation and induces apoptosis in a human uterine leiomyoma (utlm) cell line but does not demonstrate a significant cytotoxic effect in a normal human uterine smooth muscle (utsm) cell line. Title = effects of adlay hull and testa ethanolic extracts on the growth of uterine leiomyoma cells, abstract = uterine leiomyoma has become a significant health concern affecting one in forth women in reproductive age in taiwan, according to the ministry of health and welfare. The cells in uterine fibroids is markedly abnormal and the growth of human fibroid cells and eventually increased the death rate of these cells growth factors are chemicals secreted by cells which uterine leiomyoma research (february 2005.